Human papillomavirus type 16 E6 inhibits p21WAF1 transcription independently of p53 by inactivating p150Sal2

WAF1, a potential mediator of p53 tumor suppression

Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell · 1993 · 8.4K citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Jay P. Morgenstern, Hartmut Land · Nucleic Acids Research · 1990 · 2.1K citations · Full text

Viral Replication, Engineering, Medicine +15

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

Junjie Chen, Peter K. Jackson, Marc W. Kirschner et al. · Nature · 1995 · 554 citations

Signal Transduction, Signaling Pathway, Molecular Pathway +9

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

Jens Oliver Funk, S Waga, Jo Beth Harry et al. · Genes & Development · 1997 · 513 citations · Full text

Viral Replication, Pcna-binding Site, Molecular Biology +16

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

D. Leanne Jones, Rhoda M. Alani, Karl Münger · Genes & Development · 1997 · 459 citations · Full text