Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Friedländer reaction on 2-amino-3-cyano-4H-pyrans: Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analogues

A. MARTINEZ‐GRAU, JoséL Marco · Bioorganic & Medicinal Chemistry Letters · 1997 · 319 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease

Albert Badia, Josep-Eladı́ Baños, Pelayo Camps et al. · Bioorganic & Medicinal Chemistry · 1998 · 80 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties

V. Gregor, Mark R. Emmerling, Chitase Lee et al. · Bioorganic & Medicinal Chemistry Letters · 1992 · 53 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14

Reactions of six-membered heterocyclic β-enaminonitriles with electrophilic reagents

Salem E. Zayed, Eiman I. Abou Elmaged, Saud A. Metwally et al. · Collection of Czechoslovak Chemical Communications · 1991 · 33 citations

Natural Sciences, Chemistry, Medicinal Chemistry +11