Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.6K citations

Biochemistry, Acetylcholinesterase Activity, Medicine +4

Friedländer reaction on 2-amino-3-cyano-4H-pyrans: Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analogues

A. MARTINEZ‐GRAU, JoséL Marco · Bioorganic & Medicinal Chemistry Letters · 1997 · 311 citations

Derivatives, Friedländer Reaction, Biochemistry +6

Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease

Albert Badia, Josep-Eladı́ Baños, Pelayo Camps et al. · Bioorganic & Medicinal Chemistry · 1998 · 79 citations

Molecular Pharmacology, Medicinal Chemistry, Alzheimer's Disease +10

The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties

V. Gregor, Mark R. Emmerling, Chitase Lee et al. · Bioorganic & Medicinal Chemistry Letters · 1992 · 53 citations

Medicinal Chemistry, Biochemistry, Medicine +8

Reactions of six-membered heterocyclic β-enaminonitriles with electrophilic reagents

Salem E. Zayed, Eiman I. Abou Elmaged, Saud A. Metwally et al. · Collection of Czechoslovak Chemical Communications · 1991 · 33 citations

Pyridinethione Viii, Heterocyclic, Electrophilic Reagents +8