The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties

Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein

Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science · 1991 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +17

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

William K. Summers, Lawrence V. Majovski, Gary M. Marsh et al. · New England Journal of Medicine · 1986 · 1.2K citations

Medicine, Neurology, Pharmacology +15

A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations

Carl D. Johnson, Richard L. Russell · Analytical Biochemistry · 1975 · 691 citations

Life Sciences, Biochemistry, Chemistry +9

Mechanisms of cholinesterase inhibition in senile dementia of the alzheimer type: Clinical, pharmacological, and therapeutic aspects

Robert E. Becker · Drug Development Research · 1988 · 197 citations

Medicine, Neuroscience, Pharmacology +17

9-Amino-1,2,3,4-tetrahydroacridin-1-ols. Synthesis and evaluation as potential Alzheimer's disease therapeutics

G. M. SHUTSKE, Frank A. Pierrat, Kevin J. Kapples et al. · Journal of Medicinal Chemistry · 1989 · 104 citations · Full text

Medicine, Neuroscience, Pharmacology +17