Concepedia

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

Nicolai Savaskan, Alexandra Heckel, Eric Hahnen, Tobias Engelhorn, Arnd Doerfler, Oliver Ganslandt, Christopher Nimsky, Michael Buchfelder, Ilker Y. Eyüpoglu

Nature Medicine · 2008 · 187 citations · 7 references

DOI

Concepts

References

7

Glutamate release promotes growth of malignant gliomas

Takahiro Takano, Jane H.-C. Lin, Gregory Arcuino et al. · Nature Medicine · 2001 · 592 citations

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Glioma cells release excitotoxic concentrations of glutamate.

Zu‐Cheng Ye, Harald Sontheimer · PubMed · 1999 · 447 citations

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Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

Shogo Ishiuchi, Keisuke Tsuzuki, Yukari Yoshida et al. · Nature Medicine · 2002 · 328 citations

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Cystine/Glutamate Exchange Modulates Glutathione Supply for Neuroprotection from Oxidative Stress and Cell Proliferation

Andy Y. Shih, Heidi Erb, Xiao‐Jian Sun et al. · Journal of Neuroscience · 2006 · 316 citations · Full text

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Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors

Wook Joon Chung, Susan A. Lyons, Gina M. Nelson et al. · Journal of Neuroscience · 2005 · 313 citations · Full text

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