In vivo simulated in vitro model of Jasminum sambac (Linn.) using mammalian liver slice technique

Abstract

To evaluate the antioxidant status of Jasminum sambac (J. sambac) using mammalian liver slice technique in in vivo simulated in vitro model. Antioxidant activity of J. sambac was studied against H2O2 induced free radicals in goat liver. Administration of H2O2 showed significant decline in the levels of antioxidant enzymes in liver homogenate. Pretreatment with J. sambac had significant protection in those levels within normal range. Also the plant normalized the lipid peroxidation which evidently showed that the methanolic extract ofJ. sambac had a potent antilipid peroxidative effect. The present study suggests that J. sambac has a potent antioxidant effect and it can be used to treat various diseases caused by free radicals.