Heck−Suzuki−Miyaura Domino Reactions Involving Ynamides. An Efficient Access to 3-(Arylmethylene)isoindolinones

Abstract

[reaction: see text] Substituted 3-(arylmethylene)isoindolin-1-ones can be efficiently synthesized in a stereoselective manner from various ynamides and boronic acids by palladium-catalyzed Heck-Suzuki-Miyaura domino reactions.