The First Stereoselective Ficini−Claisen Rearrangement Using Chiral Ynamides

Abstract

The first asymmetric Ficini−Claisen rearrangement using chiral ynamides is described. At relatively low temperatures, the Ficini−Claisen rearrangement can be efficiently promoted by p-nitrobenzenesulfonic acid leading to high diastereoselectivity for a range of different allylic alcohols and chiral ynamides.