Concepedia

Cotransplantation With Xenogenetic Neonatal Porcine Sertoli Cells Significantly Prolongs Islet Allograft Survival in Nonimmunosuppressive Rats

Zhuzeng Yin, Dong Chen, Feng Hu, Yongle Ruan, Junhua Li, Lu Wang, Ying Xiang, Lin Xie, Ximo Wang, Thomas E. Ichim,

Transplantation · 2009 · 26 citations · 24 references

DOI

Abstract

These data suggest that xenogeneic Sertoli cells exert a global immune suppressive effect that extends across species barriers in a stringent model of alloimmune rejection. The combination of NPSCs with other immune modulatory regimes may yield novel approaches toward prevention of allo-islet transplant rejection.

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24

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