Concepedia

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

Sheila Μ. Thomas, Michael DeMarco, Gabriella D’Arcangelo, Simon Halegoua, Joan S. Brugge

Cell · 1992 · 703 citations · 62 references

DOI

Concepts

References

62

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

Teri G. Boulton, Steven H. Nye, David J. Robbins et al. · Cell · 1991 · 1.9K citations

, , +10

The trk proto-oncogene encodes a receptor for nerve growth factor

Rüdiger Klein, Venkata Nanduri, Edward C. O’Rourke et al. · Cell · 1991 · 1.4K citations

, , +14

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

Barbara L. Hempstead, Dionisio Martı́n-Zanca, David R. Kaplan et al. · Nature · 1991 · 1.2K citations

, , +16

A Cytoplasmic Protein Stimulates Normal N- <i>ras</i> p21 GTPase, But Does Not Affect Oncogenic Mutants

Meg Trahey, Frank McCormick · Science · 1987 · 1.2K citations

, , +13

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

Neil G. Anderson, James L. Maller, N. K. Tonks et al. · Nature · 1990 · 1.1K citations

, , +14