Predicting the human teratogenic potential of the anticonvulsant, valproic acid, from a non-human primate model

Epilepsy and Pregnancy: A Report from the Oxford Record Linkage Study

Jean Fedrick · BMJ · 1973 · 233 citations · Full text

Public Health, Maternal Health, Obstetrics +14

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

Heinz Nau, D. Rating, S. Koch et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 231 citations

Medicine, Pharmacokinetics, Pharmacology +17

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

Heinz Nau, Rainer Zierer, Horst Spielmann et al. · Life Sciences · 1981 · 169 citations

Pharmacy, Pharmacokinetics, Toxicology +17

Teratogenicity of valproic acid: In vivo and in vitro investigations

John Y. Kao, Nigel A. Brown, Eugenia H. Goulding et al. · Teratogenesis Carcinogenesis and Mutagenesis · 1981 · 163 citations

Life Sciences, Developmental Biology, Pharmacology +17

Teratogenic valproic acid concentrations: Infusion by implanted minipumps vs conventional injection regimen in the mouse

Heinz Nau · Toxicology and Applied Pharmacology · 1985 · 158 citations

Pharmacy, Pharmacokinetics, Pharmacology +6