A PEGA resin for use in the solid-phase chemical–enzymatic synthesis of glycopeptides

Abstract

The successful application of a new resin consisting of beaded polyethylene glycol polyacrylamide copolymer 5(PEGA1900) as a solid support for the chemical–enzymatic synthesis of glycopeptides is reported; the resin is mechanically stable, yet highly swelling in both organic solvents and aqueous buffers.