Hepatotoxic Reaction to lodipamide Meglumine Injection

Abstract

HEPATOTOXIC reactions resulting from the use of cholecystographic and cholangiographic contrast media have been understandably rare.^1,2A patient without known preexisting liver disease who sustained a clinically mild but chemically severe hepatotoxic reaction was recently studied at Tucson Medical Center; the suspected responsible agent was iodipamide meglumine injection. <h3>Report of a Case</h3> A 66-year-old woman was seen one week before admission because of recent onset of periumbilical pain. No other notable gastrointestinal symptoms were present. A cholecystectomy had been performed two years previously. The findings of the initial physical examination were entirely normal. Results of a complete blood cell count (CBC), determination of erythrocyte sedimentation rate, urinalysis, electrocardiogram, and complete liver function tests (Table) obtained six days before admission were all well within normal limits. A plain x-ray film of the abdomen revealed a prominent calcification in the right upper quadrant. An intravenous cholangiogram performed by infusion of 60