Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

Della David, Noah Ollikainen, Jonathan C. Trinidad et al. · PLoS Biology · 2010 · 650 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome

Xavier Altafaj · Human Molecular Genetics · 2001 · 394 citations

Life Sciences, Genetics, Neuroscience +17

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

Desmond Smith, Mary E. Stevens, Sharmila P. Sudanagunta et al. · Nature Genetics · 1997 · 320 citations

Life Sciences, Genetics, Neuroscience +15

DYRK1A-mediated Hyperphosphorylation of Tau

Soo‐Ryoon Ryoo, Hey Kyeong Jeong, Chinzorig Radnaabazar et al. · Journal of Biological Chemistry · 2007 · 271 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +13

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

Fei Liu, Zhihou Liang, Jerzy Węgiel et al. · The FASEB Journal · 2008 · 264 citations

Life Sciences, Genetics, Neuroscience +17