Nonhydrolytic Pathway in Metabolism of <i>N</i> -Methylcarbamate Insecticides

Abstract

Sevin (1-naphthyl N-methylcarbamate), when metabolized by rat liver microsomes and insects, yielded at least five carbamate metabolites involving modification of both the methyl group and ring. Certain of these metabolites appeared in milk when Sevin was fed to a goat. The metabolism of o-isopropoxyphenyl N-methylcarbamate by liver microsomes, insects, and plants was compared to that of Sevin.