Concepedia

Synthesis and Biological Evaluation of Novel Rigid 1,4‐Benzodiazepine‐2,5‐dione Chimeric Scaffolds

Ana C. Araújo, Francesco Nicotra, Cristina Airoldi, Barbara Costa, Gabriella Giagnoni, Pietro Fumagalli, Laura Cipolla

European Journal of Organic Chemistry · 2007 · 21 citations · 26 references

DOI

Concepts

Abstract

Abstract Novel, conformationally constrained 1,4‐benzodiazepine‐2,5‐diones containing both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric scaffolds; preliminary biological evaluation as GABA A receptor ligands is reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

References

26

NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

Hugo E. Gottlieb, Vadim Kotlyar, Abraham Nudelman · The Journal of Organic Chemistry · 1997 · 3.7K citations

, , +5

Pharmacophore/Receptor Models for GABA<sub>A</sub>/BzR Subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) via a Comprehensive Ligand-Mapping Approach

Qi Huang, Xiaohui He, Chunrong Ma et al. · Journal of Medicinal Chemistry · 1999 · 135 citations · Full text

, , +17

Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists

Martin H. Bolli, Judith Marfurt, Corinna Grisostomi et al. · Journal of Medicinal Chemistry · 2004 · 77 citations · Full text

, , +12

Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

James M. Samanen, Fadia E. Ali, Linda S. Barton et al. · Journal of Medicinal Chemistry · 1996 · 72 citations · Full text

, , +8

Design, Synthesis, and Evaluation of a Novel Sequence-Selective Epoxide-Containing DNA Cross-Linking Agent Based on the Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine System

Stuart C. Wilson, Philip W. Howard, Stephen Forrow et al. · Journal of Medicinal Chemistry · 1999 · 64 citations

, , +11