Synthesis and in vitro anti-HIV activities of amphiphilic heterodinucleoside phosphate derivatives containing the 2',3'-dideoxynucleosides ddC, AZT and ddI

Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals

JH Darbyshire · The Lancet · 1996 · 515 citations

Pharmacy, Pharmacology, Pharmacotherapy +14

3′-azido-3′-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion.

Thomas P. Zimmerman, William B. Mahony, Karen Prus · Journal of Biological Chemistry · 1987 · 224 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Prodrugs of phosphates, phosphonates, and phosphinates

Jeffrey P. Krise, Valentino J. Stella · Advanced Drug Delivery Reviews · 1996 · 175 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +5

Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

Raymond F. Schinazi, J P Sommadossi, Vanessa Saalmann et al. · Antimicrobial Agents and Chemotherapy · 1990 · 173 citations · Full text

Life Sciences, Immunology, Molecular Biology +8

Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2',3'-dideoxycytidine in vitro

Joseph J. Eron, Victoria A. Johnson, Debra P. Merrill et al. · Antimicrobial Agents and Chemotherapy · 1992 · 62 citations · Full text

Medicine, Infectious Diseases, Pharmacology +17