Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

Bruno Luckow, Günther Schütz · Nucleic Acids Research · 1987 · 1.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

Thomas M. DeChiara, Argiris Efstratiadis, Elizabeth J. Robertsen · Nature · 1990 · 1.7K citations

Medicine, Genetics, Molecular Genetics +13

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

Andrew P. McMahon, Allan Bradley · Cell · 1990 · 1.5K citations

Life Sciences, Developmental Biology, Genetics +11

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Victor L. J. Tybulewicz, C. Crawford, Peter K. Jackson et al. · Cell · 1991 · 1.3K citations

Medicine, Genetics, Molecular Biology +15