The complement system in rheumatoid synovitis i. an analysis of complement component activities in rheumatoid synovial fluids

Abstract

Abstract Stoichiometric hemolytic assays were used to measure the activities of the first four reacting components of the complement sequence in synovial fluids from patients with seropositive or seronegative rheumatoid arthritis or degenerative joint disease. The pattern of component reductions in the seropositive rheumatoid arthritis fluids was consistent with activation of the complement system by an intra‐articular immunologic process.