Proceedings of the National Academy of Sciences · 1969 · 77 citations · 8 references
PharmacyPharmacokineticsPharmacologyDrug MetabolismExperimental PharmacologyHepatic PharmacokineticsDrug DispositionHepatic ClearanceHepatic Drug ClearanceHepatic Drug DistributionHepatic Drug MetabolismHepatic MetabolismHepatic Drug AccumulationHepatic Drug DispositionHepatic Transport Of MetabolitesHepatic TransportersHepatic Uptake KineticsHepatic Uptake Of XenobioticsHepatocyte Uptake
The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.
8