A benzo[a]pyrene -7,8-dihydrodiol-9,10-epoxide is the major metabolite involved in the binding of benzo[a]pyrene to DNA in isolated viable rat hepatocytes

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Peter Sims, P.L. Grover, Alan Swaisland et al. · Nature · 1974 · 1.1K citations

Life Sciences, Biochemistry, Metabolism +12

Arene Oxides: A New Aspect of Drug Metabolism

D. M. JERINA, John W. Daly · Science · 1974 · 1K citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

P. Brookes, P.D. Lawley · Nature · 1964 · 678 citations

Pharmacy, Molecular Biology, Toxicology +17

Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid

A. Borgen, H. Darvey, Neal Castagnoli et al. · Journal of Medicinal Chemistry · 1973 · 311 citations

Life Sciences, Biochemistry, Pharmacology +10

Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

A.M. Jeffrey, I. Bernard Weinstein, K. W. Jennette et al. · Nature · 1977 · 296 citations

Life Sciences, Biochemistry, Molecular Biology +11