The Entropy Balance of Nostocyclopeptide Macrocyclization Analysed by NMR Spectroscopy

Abstract

Overcoming the problem of irreversibility: In spite of their relevance in biology and synthetic chemistry, biomolecular macrocyclizations still lack quantitative experimental description. The establishment of an imino peptide ring-chain equilibrium allows the determination of the entropy balance involved in macrocyclization. By comparing the backbone dynamics and cyclization behaviour of the modified nostocyclopeptides we can characterise the role of preorientation in the cyclization process.