Concepedia

Backbone Dynamics

Backbone Dynamics is a biophysical concept that refers to the time-dependent structural fluctuations of the polypeptide backbone in proteins, distinguished from side-chain dynamics by its focus on the conformational flexibility of the main chain atoms (N–Cα–C′) underlying protein function and folding.

646

Publications

38K

Citations

2.3K

Authors

613

Institutions

Publications per year

2017–2026

56

Parents

Publications

646

Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation

Neil A. Farrow, Ranjith Muhandiram, Alex U. Singer et al. · Biochemistry · 1994 · 2.1K citations

, , +16

Backbone dynamics of proteins as studied by nitrogen-15 inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease

Dennis A. Torchia, Ad Bax · Biochemistry · 1989 · 1.8K citations

, , +16

Backbone Dynamics of Ribonuclease HI: Correlations with Structure and Function in an Active Enzyme

Arthur M. Mandel, Mikael Akke, Arthur G. Palmer · Journal of Molecular Biology · 1995 · 995 citations · Full text

, , +17

Backbone dynamics of calmodulin studied by nitrogen-15 relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible

Gaetano Barbato, Mitsuhiko Ikura, Lewis E. Kay et al. · Biochemistry · 1992 · 900 citations

, , +17

Large-amplitude nonlinear motions in proteins

Angel E. Garcı́a · Physical Review Letters · 1992 · 798 citations

, , +17

1–5 of 646

Authors

2.3K

  1. AG
    Arthur G. Palmer

    Columbia University, United States

    15 publications · 2.5K citations

    15

    h-index

  2. MB
    Martin Blackledge

    Institut de Biologie Structurale, France

    12 publications · 710 citations

    11

    h-index

  3. BD
    Brian D. Sykes

    University of Alberta, Canada

    11 publications · 380 citations

    11

    h-index

  4. RB
    Rafael Brüschweiler

    Florida State University, United States

    9 publications · 853 citations

    9

    h-index

  5. PE
    Peter E. Wright

    Scripps Research Institute, United States

    9 publications · 1K citations

    9

    h-index

1–5 of 2.3K

Institutions

613

  1. National Institutes of Health

    Bethesda, United States

    23 h-index

    85 publications

    8.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    19 h-index

    115 publications

    4.4K citations

  3. Scripps Research Institute

    San Diego, United States

    18 h-index

    66 publications

    5.8K citations

  4. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    16 h-index

    45 publications

    8.4K citations

  5. Institut de Biologie Structurale

    Grenoble, France

    14 h-index

    51 publications

    2.8K citations

  6. Columbia University

    New York, United States

    14 h-index

    50 publications

    7.8K citations

  7. University of Alberta

    Edmonton, Canada

    13 h-index

    36 publications

    1.5K citations

  8. Cornell University

    Ithaca, United States

    13 h-index

    44 publications

    3K citations

1–8 of 613

Venues

  1. Biochemistry

    191 publications · 15K citations

    54

    h-index

  2. Journal of the American Chemical Society

    JACS · 56 publications · 4K citations

    39

    h-index

  3. Journal of Molecular Biology

    JMB · 52 publications · 4.3K citations

    35

    h-index

  4. Protein Science

    PS · 44 publications · 1.7K citations

    25

    h-index

  5. Journal of Biological Chemistry

    JBC · 24 publications · 903 citations

    20

    h-index

1–5