Concepedia

Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious κ-Opioid Receptor Agonist: Structural and Functional Considerations

Charles Chavkin, Sumit Sud, Wenzhen Jin, Jeremy Stewart, Jordan K. Zjawiony, Daniel J. Siebert, Beth Ann Toth, Sandra J. Hufeisen, Bryan L. Roth

Journal of Pharmacology and Experimental Therapeutics · 2004 · 212 citations · 22 references

DOI

Concepts

References

22

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

Charles Chavkin, Iain F. James, Avram Goldstein · Science · 1982 · 1.2K citations

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Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

Bryan L. Roth, Karen Baner, Richard B. Westkaemper et al. · Proceedings of the National Academy of Sciences · 2002 · 780 citations · Full text

, , +11

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

Bruce R. Conklin, Zvi Farfel, Kevin D. Lustig et al. · Nature · 1993 · 736 citations

, , +12

Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C

Stefan Offermanns, Melvin I. Simon · Journal of Biological Chemistry · 1995 · 505 citations · Full text

, , +17

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.

Jay P. McLaughlin, Monica Marton-Popovici, Charles Chavkin · PubMed · 2003 · 480 citations · Full text

, , +17