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Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate

Lilli Anselm, David W. Banner, Jörg Benz, Katrin Groebke Zbinden, Jacques Himber, Hans Hilpert, Walter Huber, Bernd Kuhn, Jean‐Luc Mary, Michael B. Otteneder,

Bioorganic & Medicinal Chemistry Letters · 2010 · 41 citations · 24 references

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24

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31.4K citations · Full text

, , +17

The CCP4 suite: programs for protein crystallography

Number Collaborative Computational Project · Acta Crystallographica Section D Biological Crystallography · 1994 · 17.3K citations

, , +15

Crystallography &amp; NMR System: A New Software Suite for Macromolecular Structure Determination

Axel T. Brünger, Paul D. Adams, G. Marius Clore et al. · Acta Crystallographica Section D Biological Crystallography · 1998 · 15.8K citations

, , +17

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

Garib N. Murshudov, A. A. Vagin, E. J. Dodson · Acta Crystallographica Section D Biological Crystallography · 1997 · 14.9K citations

, , +13

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

Wolfgang Kabsch · Journal of Applied Crystallography · 1993 · 3.6K citations

, , +16