Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

Anne J. Ridley, Alan Hall · Cell · 1992 · 4.5K citations

Life Sciences, Cell Biology, Molecular Biology +17

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Concepción Almoguera, Darryl Shibata, Kathleen Forrester et al. · Cell · 1988 · 2.1K citations

Medicine, Molecular Genetics, Oncology +10

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by <i>ras</i> Proteins

Dafna Bar‐Sagi, James R. Feramisco · Science · 1986 · 737 citations

Life Sciences, Cell Biology, Molecular Biology +15

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

Ralph H. Hruban, A D van Mansfeld, G.J.A. Offerhaus et al. · PubMed · 1993 · 653 citations

Medicine, Molecular Genetics, Oncology +15