Highly Concentrated Monoclonal Antibody Solutions: Direct Analysis of Physical Structure and Thermal Stability

Examination of the secondary structure of proteins by deconvolved FTIR spectra

D. Michael Byler, H. Susi · Biopolymers · 1986 · 3K citations

Life Sciences, Biochemistry, Biophysics +14

Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +12

The Thermal Stability of Immunoglobulin: Unfolding and Aggregation of a Multi-Domain Protein

Arnoldus W. P. Vermeer, Willem Norde · Biophysical Journal · 2000 · 666 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous Solution

Jun Liu, Mary D.H. Nguyen, James D. Andya et al. · Journal of Pharmaceutical Sciences · 2005 · 439 citations

Pharmacy, Biochemistry, Immunology +15

Effect of Dextran on Protein Stability and Conformation Attributed to Macromolecular Crowding

Kenji Sasahara, Peter McPhie, Allen P. Minton · Journal of Molecular Biology · 2003 · 319 citations

Natural Sciences, Biochemistry, Biophysics +16