2-Aminobenzophenones as a Novel Class of Bradykinin B<sub>1</sub>Receptor Antagonists - Concepedia

Concepedia

Publication | Open Access

2-Aminobenzophenones as a Novel Class of Bradykinin B<sub>1</sub>Receptor Antagonists

DOI Full Paper Access

16

Citations

0

References

2008

Year

Dai‐Shi Su, John L. Lim, Elizabeth Tinney, Bang-Lin Wan, Kathy Murphy, Duane R. Reiss, C. Meacham Harrell, Stacy S. O’Malley, Rick W. Ransom, Raymond S.L. Chang,

Journal of Medicinal Chemistry

Abstract

Selective bradykinin (BK) B 1 receptor antagonists could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure activity relationships of the structurally novel HTS lead compound 1 provided potent hBK B 1 receptor antagonists with excellent receptor occupancy in the CNS of hBK B 1 transgenic rats.