Duane R. Reiss

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 370 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +12

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

Christopher J. Winrow, Anthony L. Gotter, Christopher D. Cox et al. · Journal of Neurogenetics · 2011 · 270 citations

Medicine, Neuroscience, Pharmacology +16

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α_1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

James C. Barrow, Philippe G. Nantermet, Harold G. Selnick et al. · Journal of Medicinal Chemistry · 2000 · 223 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066.

Bradley V. Clineschmidt, Douglas J. Pettibone, Victor J. Lotti et al. · Journal of Pharmacology and Experimental Therapeutics · 1988 · 132 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties

Paul J. Coleman, John D. Schreier, Christopher D. Cox et al. · ChemMedChem · 2012 · 124 citations

Medicine, Medicinal Chemistry, Pharmacology +17