Mental Retardation and Developmental Disabilities Research Reviews · 2002 · 238 citations · 52 references
Public HealthChild HealthPediatricsDisabilityPediatric DisabilityPediatric EpidemiologyChildren With DisabilitiesDevelopmental DisabilitiesDevelopmental DisordersGenetic DisordersNeurodevelopmental DisordersNeurodevelopmental EpidemiologyDisability Etiology
Most children in developing countries are at high risk for developmental disabilities, yet prevalence, causes, and prevention methods remain poorly understood, with trauma, toxic exposures, and preventable risk factors largely undocumented. The study aims to highlight methodological challenges, summarize current epidemiological knowledge, and emphasize the need for epidemiologic research to inform priorities and interventions for developmental disabilities in low‑income countries. The paper reviews methodological challenges in data collection and identifies key risk factors such as genetic diseases, advanced maternal age, consanguinity, micronutrient deficiencies, and infections. Prevalence of developmental disabilities is higher in low‑income countries, with severe mental retardation reported at over 5 per 1,000 children versus lower rates in industrialized nations, despite higher mortality among affected children. © 2002 Wiley‑Liss, Inc.; MRDD Research Reviews 2002;8:206–211.
Abstract Although most of the world's children live in developing countries and may be at high risk for disability, very little is known about the prevalence and causes of developmental disabilities in these countries. This paper discusses methodological difficulties contributing to this lack of knowledge, and provides an overview of what is known about the epidemiology of developmental disabilities in low‐income countries. At least some forms of developmental disability appear to be more common in low‐income countries than in wealthier countries, despite the probability of higher mortality among children with disabilities in low‐income countries. For example, most studies of severe mental retardation in low‐income countries report prevalences greater than 5 per 1,000 children, while prevalence estimates from industrialized countries are consistently below this. Major risk factors for developmental disabilities in some low‐income countries include specific genetic diseases, a higher frequency of births to older mothers, consanguinity, and specific micronutrient deficiencies and infections. Trauma and toxic exposures are also important risk factors, but their contributions to the etiology of developmental disabilities in low‐income countries are not well documented. Though many of the causes of developmental disabilities are understood and preventable, proven methods of prevention are not being fully implemented in developing countries. Epidemiologic studies are needed to raise awareness of the public health impacts of developmental disabilities in low‐income countries and to provide a basis for setting priorities and designing efficient interventions. MRDD Research Reviews 2002;8:206–211. © 2002 Wiley‐Liss, Inc.
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Prevention of Neural-Tube Defects with Folic Acid in China
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