Epistatic Effect of TLR4 and IL4 Genes on the Risk of Asthma in Females

Kati Ådjers, Jussi Karjalainen, Tanja Pessi, Carita Eklund, Mikko Hurme

International Archives of Allergy and Immunology · 2005 · 43 citations · 30 references

Abstract

Our results indicate that in females the TLR4 and IL4 genes show an epistatic effect on the risk of asthma. The low LPS-responsive allele G of TLR4 and high IgE production allele T of IL4 were found to be the predisposing combination. However, there was no epistatic effect on the risk of atopy.

References

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