Concepedia

Regulation of theDrosophilabHLH-PAS Protein Sima by Hypoxia: Functional Evidence for Homology with Mammalian HIF-1α

N. C. M. Bacon, Pablo Wappner, John F. O’Rourke, Sylvia M. Bartlett, Christopher W. Pugh, Peter J. Ratcliffe

Biochemical and Biophysical Research Communications · 1998 · 81 citations · 24 references

DOI

Concepts

References

24

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Gregg L. Semenza, G.L. Wang · Molecular and Cellular Biology · 1992 · 2.4K citations · Full text

, , +17

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Hui-Qiao Tian, Steven L. McKnight, David W. Russell · Genes & Development · 1997 · 1.3K citations · Full text

, , +16

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

Eric Huang, Zoltàn Arany, David M. Livingston et al. · Journal of Biological Chemistry · 1996 · 1.2K citations · Full text

, , +16

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the <i>VEGF</i> expression and is potentially involved in lung and vascular development

Masatsugu Ema, Shin-ichiro Taya, Noboru Yokotani et al. · Proceedings of the National Academy of Sciences · 1997 · 1K citations · Full text

, , +13