Concepedia

Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer's disease

Eugene Drigalenko, Shirley E. Poduslo, Robert C. Elston

Neurology · 1998 · 35 citations · 12 references

DOI

Abstract

Association of AD with both the ApoE epsilon4 and ApoCI A alleles was found. The increased risk of AD among carriers of epsilon4 was found to be higher among those who also bear the ApoCI A allele but this may be due to a dose effect of the epsilon4 allele.

References

12

Clinical diagnosis of Alzheimer's disease

Guy M. McKhann, David A. Drachman, Marshall Folstein et al. · Neurology · 1984 · 27.8K citations · Full text

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

, , +9

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva et al. · Nature · 1995 · 4K citations

, , +7

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Ann M. Saunders, Warren J. Strittmatter, D. E. Schmechel et al. · Neurology · 1993 · 3.8K citations · Full text

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

D.T. Vernier · Journal of Lipid Research · 1990 · 2.9K citations · Full text