The effect of metronidazole on the cell cycle and DNA in metronidazole-susceptible and -resistant Giardia cell lines

Genome ploidy in different stages of the Giardia lamblia life cycle

Rolf Bernander, Joy Palm, Staffan G. Svärd · Cellular Microbiology · 2001 · 269 citations

Comparative Genomics, Genetics, Genomics +22

<i>Trichomonas vaginalis</i>: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance

David Leitsch, Daniel Kolarich, Marina Binder et al. · Molecular Microbiology · 2009 · 167 citations · Full text

Antiparasitic Agent, Redox Biology, Thioredoxin Peroxidase +18

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

Gerard Manning, David S. Reiner, Tineke Lauwaet et al. · Genome biology · 2011 · 145 citations · Full text

Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

David Leitsch, Anita G. Burgess, Linda A. Dunn et al. · Journal of Antimicrobial Chemotherapy · 2011 · 130 citations · Full text

Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in <i>Helicobacter pylori</i> and in <i>Escherichia coli</i> Containing a Cloned <i>H. pylori rdxA</i> ⁺ (Nitroreductase) Gene

Gary Sisson, Jin-Yong Jeong, Avery Goodwin et al. · Journal of Bacteriology · 2000 · 126 citations · Full text