Avery Goodwin

Metronidazole resistance in <i>Helicobacter pylori</i> is due to null mutations in a gene (<i>rdxA</i>) that encodes an oxygen‐insensitive NADPH nitroreductase

Avery Goodwin, Dangeruta Kersulyte, Gary Sisson et al. · Molecular Microbiology · 1998 · 352 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in <i>Helicobacter pylori</i>

Gary Sisson, Avery Goodwin, Aušra Raudonikiene et al. · Antimicrobial Agents and Chemotherapy · 2002 · 164 citations · Full text

Life Sciences, Microbiology, Pharmacology +16

Sequential Inactivation of <i>rdxA</i> (HP0954) and <i>frxA</i> (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in <i>Helicobacter pylori</i>

Jin-Yong Jeong, Asish K. Mukhopadhyay, Daiva Dailidiene et al. · Journal of Bacteriology · 2000 · 138 citations · Full text

Life Sciences, Genetics, Microbiology +14

Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in <i>Helicobacter pylori</i> and in <i>Escherichia coli</i> Containing a Cloned <i>H. pylori rdxA</i> ⁺ (Nitroreductase) Gene

Gary Sisson, Jin-Yong Jeong, Avery Goodwin et al. · Journal of Bacteriology · 2000 · 127 citations · Full text

Life Sciences, Microbiology, Molecular Biology +13

Metabolic activities of metronidazole-sensitive and -resistant strains of Helicobacter pylori: repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistance

Paul S. Hoffman, Avery Goodwin, Jürgen Johnsen et al. · Journal of Bacteriology · 1996 · 118 citations · Full text

Life Sciences, Biochemistry, Microbiology +15