Protection against bronchial asthma by CFTR ΔF508 mutation: A heterozygote advantage in cystic fibrosis

The origin of the major cystic fibrosis mutation (ΔF508) in European populations

Núria Morral, Jaume Bertranpetit, Xavier Estivill et al. · Nature Genetics · 1994 · 347 citations

Life Sciences, Genetics, Molecular Genetics +12

Coronary thrombolysis and myocardial salvage by tissue plasminogen activator given up to 4 hours after onset of myocardial infarction

Peter L. Thompson, Philip E. Aylward, J. Federman et al. · The Lancet · 1988 · 287 citations

Medicine, Cardiology, Pharmacology +17

Mutation Analysis for Heterozygote Detection and the Prenatal Diagnosis of Cystic Fibrosis

Wanda K. Lemna, Gerald L. Feldman, Batsheva Kerem et al. · New England Journal of Medicine · 1990 · 223 citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Increased incidence of cystic fibrosis gene mutations in adults with disseminated bronchiectasis

Pier Franco Pignatti, Cristina Bombieri, Cristina Marigo et al. · Human Molecular Genetics · 1995 · 193 citations

Medicine, Genetics, Molecular Genetics +14

Detecting multiple cystic fibrosis mutations by polymerase chain reaction-mediated site-directed mutagenesis

Kenneth J. Friedman, W. Edward Highsmith, Lawrence M. Silverman · Clinical Chemistry · 1991 · 85 citations

Life Sciences, Genetics, Molecular Genetics +17