Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.6K citations

Life Sciences, Immunology, Molecular Biology +17

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Life Sciences, Immunology, Microbiology +13

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Samuel D. Wright, Robert Ramos, Peter S. Tobias et al. · Science · 1990 · 4K citations

Life Sciences, Biochemistry, Immunology +16

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Bruno Lemaître, Émmanuelle Nicolas, Lydia Michaut et al. · Cell · 1996 · 4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Life Sciences, Genetics, Immunology +15