The endothelial saga: the past, the present, the future

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

Robert F. Furchgott, John V. Zawadzki · Nature · 1980 · 12K citations

Life Sciences, Cell Biology, Physiology +15

Vascular endothelial cells synthesize nitric oxide from L-arginine

Richard Palmer, D. Ashton, Salvador Moncada · Nature · 1988 · 4.8K citations

Life Sciences, Cell Biology, Cell Signaling +4

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

David S. Bredt, Solomon H. Snyder · Proceedings of the National Academy of Sciences · 1990 · 3.3K citations

Life Sciences, Biochemistry, Cell Biology +13

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

Ryszard J. Gryglewski, Richard Palmer, Salvador Moncada · Nature · 1986 · 2.4K citations

Life Sciences, Cell Biology, Physiology +13

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

Paul L. Huang, Zhihong Huang, Hiroshi Mashimo et al. · Nature · 1995 · 2.1K citations

Life Sciences, Genetics, Physiology +12