Role of interleukin‐13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma

Abstract

These results imply a critical role for IL-13 in accumulation of intraepithelial eosinophils in chronic asthma, as well as in epithelial and subepithelial remodelling. In addition, they suggest that in chronic asthma, IL-13 may be capable of signalling via a pathway that does not involve IL-4Ralpha.