Absorption, Distribution, and Excretion of 14C-labeled Tacrolimus (FK506) after a Single or Repeated Ocular Instillation in Rabbits

Abstract

After the ocular instillation, FK506 is first absorbed in the cornea, conjunctiva, and nasolacrimal duct, and then the rest is distributed to digestive tract through the nasal meatus and esophagus, after which it is excreted mainly into the feces.