Topical Aldose Reductase Inhibitor Formulations for Effective Lens Drug Delivery in a Rat Model for Sugar Cataracts

Abstract

In the suspensions examined, no direct relationship between the lenticular drug levels of 2-MS and either viscosity or pH of the vehicles were observed. The observed arrest of sugar cataract formation indicated that therapeutically adequate lenticular levels of 2-MS were provided by all topical suspensions.