Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Klaus Pfeffer, T. Matsuyama, Thomas M. Kündig et al. · Cell · 1993 · 1.7K citations

Life Sciences, Immunology, Infectious Diseases +16

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

Rainer Storb, H. Joachim Deeg, John Whitehead et al. · New England Journal of Medicine · 1986 · 1.5K citations

Medicine, Hematology, Immunology +14

A novel domain within the 55 kd TNF receptor signals cell death

Louis A. Tartaglia, T. Merrill Ayres, G H Wong et al. · Cell · 1993 · 1.3K citations

Life Sciences, Immunology, Molecular Biology +14

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

Joachim Rothe, Werner Lesslauer, Hansruedi Lötscher et al. · Nature · 1993 · 1.3K citations

Life Sciences, Immunology, Microbiology +12

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

Manolis Pasparakis, Lena Alexopoulou, Vasso Episkopou et al. · The Journal of Experimental Medicine · 1996 · 1.2K citations · Full text

Life Sciences, Immunology, Pathology +15