Concepedia

Upregulated Signaling Pathways in Ruptured Human Saccular Intracranial Aneurysm Wall: An Emerging Regulative Role of Toll-Like Receptor Signaling and Nuclear Factor-κB, Hypoxia-Inducible Factor-1A, and ETS Transcription Factors

Mitja Kurki, Sanna-Kaisa Häkkinen, Juhana Frösen, Riikka Tulamo, Mikael von und zu Fraunberg, Garry Wong, Gerard Tromp, Mika Niemelä, Juha Hernesniemi, Juha E. Jääskeläinen,

Neurosurgery · 2011 · 132 citations · 45 references

DOI

Abstract

We identified pathways and candidate genes associated with the rupture of human sIA wall. Our results may provide clues to the molecular mechanism in sIA wall rupture and insight for novel therapeutic strategies to prevent rupture.

References

45

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Yoav Benjamini, Yosef Hochberg · Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1995 · 105.5K citations

, , +21

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang, Brad T. Sherman, Richard A. Lempicki · Nature Protocols · 2008 · 36.7K citations

, , +15

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Gordon K. Smyth · Statistical Applications in Genetics and Molecular Biology · 2004 · 11.9K citations

, , +21

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Rafael A. Irizarry · Biostatistics · 2003 · 10.6K citations · Full text

DAVID: Database for Annotation, Visualization, and Integrated Discovery

Glynn Dennis, Brad T. Sherman, Douglas A Hosack et al. · Genome biology · 2003 · 9.4K citations · Full text