Development of fluorinated CB2 receptor agonists for PET studies

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

William A. Devane, Aviva Breuer, Roger G. Pertwee et al. · Science · 1992 · 5.6K citations

Life Sciences, Neuroscience, Pharmacology +15

Improved protein–ligand docking using GOLD

Marcel L. Verdonk, Jason C. Cole, Michael J. Hartshorn et al. · Proteins Structure Function and Bioinformatics · 2003 · 3K citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Raphael Mechoulam, Shimon Ben‐Shabat, L Hanŭs et al. · Biochemical Pharmacology · 1995 · 2.9K citations

Life Sciences, Pharmacology, Veterinary Pharmacology +10

Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations

Sylvaine Galiègue, Sophie Mary, Jean Marchand et al. · European Journal of Biochemistry · 1995 · 1.8K citations · Full text

Life Sciences, Immunology, Neurobiology +7