Evaluation of DNA topoisomerase IIα expression provides independent prognostic information in non‐Hodgkin's lymphomas

Abstract

Our results suggest that evaluation of TopoIIalpha expression and TopoIIalpha/Ki67 ratio as cell proliferation markers provides independent prognostic information in relation to post-relapse and overall survival. Furthermore, TopoIIalpha/Ki67 ratio appears to play a key role in the identification of patients prone to early relapse.