Variable Nav1.5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn5a+/− Mouse Model - Concepedia

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Variable Nav1.5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn5a+/− Mouse Model

DOI Full Paper Access

80

Citations

25

References

2010

Year

Anne‐Laure Léoni, Bruno Gavillet, Jean‐Sébastien Rougier, Céline Marionneau, Vincent Probst, Solena Le Scouarnec, Jean‐Jacques Schott, Sophie Demolombe, Patrick Bruneval, Christopher Huang,

Abstract

Scn5a(+/-) mice show similar phenotypic heterogeneity as SCN5A-mutated patients. In Scn5a(+/-) mice, phenotype severity correlates with wild-type Na(v)1.5 protein expression.

References

	Year	Citations

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