The Journal of Organic Chemistry · 2012 · 25 citations · 42 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryChiral SeparationHeterocyclic ChemistryRetrosynthetic AnalysisStereochemical OptimizationEnantioselective Synthesis
The first enantioselective approach to 13a-methylphenanthroindolizidine alkaloids is reported, featuring an efficient stereoselective Seebach's alkylation and Pictet-Spengler cyclization. The proposed and other three most probable structures were ruled out, indicating hypoestestatin 1 needs further assignment.
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Dieter Seebàch, M. BOES, Reto Naef et al. · Journal of the American Chemical Society · 1983 · 390 citations
E Gellert · Journal of Natural Products · 1982 · 154 citations