Aprotinin inhibits thrombin formation and monocyte tissue factor in simulated cardiopulmonary bypass

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.

B Osterud, S I Rapaport · Proceedings of the National Academy of Sciences · 1977 · 796 citations · Full text

Medicine, Biochemistry, Hematology +17

Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol)

Benjamin P. Bidstrup, David Royston, Ralph N. Sapsford et al. · Journal of Thoracic and Cardiovascular Surgery · 1989 · 540 citations

Medicine, Pharmacology, Surgery +14

Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation

BG Macik, PF Neuenschwander, PC Comp · Blood · 1993 · 505 citations · Full text

Medicine, Hematology, Physiology +10

Aprotinin therapy for reoperative myocardial revascularization: A placebo-controlled study

Delos M. Cosgrove, Blaine Heric, Bruce W. Lytle et al. · The Annals of Thoracic Surgery · 1992 · 388 citations

Medicine, Cardiology, Surgery +15

Aprotinin protects platelets against the initial effect of cardiopulmonary bypass

Willem van Oeveren, Marcel P. Harder, K. J. Roozendaal et al. · Journal of Thoracic and Cardiovascular Surgery · 1990 · 374 citations

Medicine, Hematology, Surgery +11