Canonical structures for the hypervariable regions of immunoglobulins

Cyrus Chothia, Arthur M. Lesk

Journal of Molecular Biology

Immunocytochemical TechniqueProtein FoldingImmunologyMolecular BiologyCanonical Structures +3

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

David K. Moscatello, Marina Holgado-Madruga, Andrew K. Godwin, +6

PubMed

Tumor BiologyFrequent ExpressionTumoral PathologyGliomaMalignant Disease +13

Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients

Amy B. Heimberger, Roman Hlatky, Dima Suki, +5

Clinical Cancer Research

Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy.

Robert W. Schroff, Kenneth A. Foon, Shannon M. Beatty, +2

PubMed

ImmunohematologyImmunocytochemical TechniqueImmunologyImmunodominanceImmunotherapeutics +18

Human immune response to multiple injections of murine monoclonal IgG.

Daniel L. Shawler, Richard M. Bartholomew, Leia M. Smith, +1

The Journal of Immunology

Structural repertoire of the human VH segments

Cyrus Chothia, Arthur M. Lesk, Ermanno Gherardi, +5

Journal of Molecular Biology

Brain MechanismNeuroanatomyGeneticsStructural RepertoireBiological Psychology +2

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.

Peter A. Humphrey, Albert J. Wong, Bert Vogelstein, +7

Proceedings of the National Academy of Sciences

Immunocytochemical TechniqueFusion JunctionImmunologyGliomaTumor Biology +15

Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways.

Maarten L. Janmaat, Frank A.E. Kruyt, José Antonio Rodríguez, +1

PubMed

Persistent ActivityCell DeathExtracellular Signal-regulated KinaseCancer BiologyTumor Biology +15

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

Y H Xu, Nancy Richert, Seiji Ito, +2

Proceedings of the National Academy of Sciences

Cancer ResearchSignal TransductionCancer Cell BiologyPathologyCell Lines +12

Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface.

Dipa Patel, Armin Lahiji, Sheetal Patel, +4

PubMed