A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity

Dan Lu, Haifan Zhang, Henry Koo, +14

Journal of Biological Chemistry

Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways.

Kapaettu Satyamoorthy, Gang Li, Bhavesh Vaidya, +2

PubMed

Tumor BiologyLate PrimaryHealth SciencesMitogen-activated Protein KinaseTumor Growth +13

Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface.

Dipa Patel, Armin Lahiji, Sheetal Patel, +4

PubMed

p53 and apoptosis alterations in keloids and keloid fibroblasts

Daniel A. Ladin, Zizheng Hou, Dipa Patel, +4

Wound Repair and Regeneration

InflammationInciting WoundApoptosisCell DeathPathology +12

Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication

Kapaettu Satyamoorthy, Joep P. P. Muyrers, Friedegund Meier, +2

Oncogene

Signal TransductionCell RegulationMedicineGap Junctional CommunicationMelanoma +8

IgG isotype, glycosylation, and EGFR expression determine the induction of antibody-dependent cellular cytotoxicity in vitro by cetuximab

Dipa Patel, Xuemei Guo, Stanley Ng, +7

Human Antibodies

Discovery and Characterization of Novel, Potent, Non-Peptide Parathyroid Hormone-1 Receptor Antagonists

Iain M. McDonald, Carol Austin, Ildiko M. Buck, +18

Journal of Medicinal Chemistry

Pth2 ReceptorsMedicinal ChemistryBiochemistryFunctional SelectivityMedicine +11

Enhanced suppression of melanoma tumor growth and metastasis by combined therapy with anti-VEGF receptor and anti-TYRP-1/gp75 monoclonal antibodies.

Dipa Patel, Rajiv Bassi, Andrea T. Hooper, +4

PubMed

Anti-tyrp-1/gp75 Monoclonal AntibodiesImmunologyTreatment ModalitiesPathologyMelanoma Tumor Growth +16

Generation and characterization of a therapeutic human antibody to melanoma antigen TYRP1

Dipa Patel, Paul Balderes, Armin Lahiji, +9

Human Antibodies

ImmunologyImmunoeditingAntigen ProcessingMalignant MelanomaImmunotherapy +14

Conservation of receptor antagonist anti-tumor activity by epidermal growth factor receptor antibody expressed in transgenic corn seed

Dale L. Ludwig, Larry Witte, Daniel J. Hicklin, +27

Human Antibodies

Vivo KineticsTransgenic Corn SeedRefractory Colorectal CancerImmunologyImmune Checkpoint Inhibitor +10