Two Regions of Simian Virus 40 Large T-Antigen Independently Extend the Life Span of Primary C57BL/6 Mouse Embryo Fibroblasts and Cooperate in Immortalization

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.4K citations

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

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Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

James A. DeCaprio · Cell · 1988 · 1.5K citations

Life Sciences, Genetics, Molecular Biology +9

Cyclin A is required at two points in the human cell cycle.

Michele Pagano, Rainer Pepperkok, Fulvia Verde et al. · The EMBO Journal · 1992 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14